2XUM

FACTOR INHIBITING HIF (FIH) Q239H MUTANT IN COMPLEX WITH ZN(II), NOG AND ASP-SUBSTRATE PEPTIDE (20-MER)

2XUM の概要

• エントリーDOI: 10.2210/pdb2xum/pdb
• 関連するPDBエントリー: 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2W0X 2WA3 2WA4
• 分子名称: HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, ASP-SUBSTRATE PEPTIDE 2, ZINC ION, ... (6 entities in total)
• 機能のキーワード: oxidoreductase-peptide complex, non-heme, dioxygenase, oxygenase, hypoxia, metal-binding, helix-loop-helix-beta, facial triad signaling, beta-hydroxylation, transcription activator/inhibitor, oxidoreductase/peptide
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43072.50

構造登録者

Chowdhury, R.,McDonough, M.A.,Schofield, C.J. (登録日: 2010-10-19, 公開日: 2010-12-22, 最終更新日: 2023-12-20)

• 主引用文献: Yang, M.,Ge, W.,Chowdhury, R.,Claridge, T.D.,Kramer, H.B.,Schmierer, B.,McDonough, M.A.,Gong, L.,Kessler, B.M.,Ratcliffe, P.J.,Coleman, M.L.,Schofield, C.J.; Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.; J. Biol. Chem., 286:7648-7660, 2011; PubMed: 21177872; DOI: 10.1074/jbc.M110.193540

実験手法

X-RAY DIFFRACTION (2.2 Å)