2XKC

Structure of Nek2 bound to aminopyrazine compound 14

2XKC の概要

• エントリーDOI: 10.2210/pdb2xkc/pdb
• 関連するPDBエントリー: 2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP
• 分子名称: SERINE/THREONINE-PROTEIN KINASE NEK2, 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-methylbenzoic acid, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: transferase, centrosome, mitosis
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus. Isoform 1: Nucleus, nucleolus. Isoform 2: Cytoplasm: P51955
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33199.70

構造登録者

Mas-Droux, C.,Bayliss, R. (登録日: 2010-07-07, 公開日: 2010-10-27, 最終更新日: 2023-12-20)

• 主引用文献: Whelligan, D.K.,Solanki, S.,Taylor, D.,Thomson, D.W.,Cheung, K.M.,Boxall, K.,Mas-Droux, C.,Barillari, C.,Burns, S.,Grummitt, C.G.,Collins, I.,Van Montfort, R.L.,Aherne, G.W.,Bayliss, R.,Hoelder, S.; Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: Sar and Structural Characterization.; J.Med.Chem., 53:7682-, 2010; PubMed: 20936789; DOI: 10.1021/JM1008727

実験手法

X-RAY DIFFRACTION (2.5 Å)