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2XK4

Structure of Nek2 bound to aminopyrazine compound 17

Summary for 2XK4
Entry DOI10.2210/pdb2xk4/pdb
Related2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP
DescriptorSERINE/THREONINE-PROTEIN KINASE NEK2, 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-ethoxybenzoic acid, CHLORIDE ION, ... (4 entities in total)
Functional Keywordstransferase, centrosome, mitosis
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus. Isoform 1: Nucleus, nucleolus. Isoform 2: Cytoplasm: P51955
Total number of polymer chains1
Total formula weight33300.63
Authors
Mas-Droux, C.,Bayliss, R. (deposition date: 2010-07-07, release date: 2010-10-27, Last modification date: 2023-12-20)
Primary citationWhelligan, D.K.,Solanki, S.,Taylor, D.,Thomson, D.W.,Cheung, K.M.,Boxall, K.,Mas-Droux, C.,Barillari, C.,Burns, S.,Grummitt, C.G.,Collins, I.,Van Montfort, R.L.,Aherne, G.W.,Bayliss, R.,Hoelder, S.
Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: Sar and Structural Characterization.
J.Med.Chem., 53:7682-, 2010
Cited by
PubMed: 20936789
DOI: 10.1021/JM1008727
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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