2XKC

Structure of Nek2 bound to aminopyrazine compound 14

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 4VQ A 1280

Chain	Residue
A	ILE14
A	PHE148
A	GLY158
A	CYS22
A	VAL35
A	LYS37
A	MET86
A	GLU87
A	CYS89
A	GLU90
A	GLY92

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1282

Chain	Residue
A	ARG105

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1283

Chain	Residue
A	GLU110
A	ARG239

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1284

Chain	Residue
A	ARG235

---

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNVFL

Chain	Residue	Details
A	VAL137-LEU149

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"17197699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"17197699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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