2XKC

Structure of Nek2 bound to aminopyrazine compound 14

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 4VQ A 1280

Chain	Residue
A	ILE14
A	PHE148
A	GLY158
A	CYS22
A	VAL35
A	LYS37
A	MET86
A	GLU87
A	CYS89
A	GLU90
A	GLY92

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1282

Chain	Residue
A	ARG105

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1283

Chain	Residue
A	GLU110
A	ARG239

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1284

Chain	Residue
A	ARG235

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Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNVFL

Chain	Residue	Details
A	VAL137-LEU149

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP141

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE14

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	LYS37

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000305|PubMed:17197699

Chain	Residue	Details
A	THR170

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000305|PubMed:17197699, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER171

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:17197699

Chain	Residue	Details
A	THR175
A	THR179

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER184

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:17197699

Chain	Residue	Details
A	SER241

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