2XKC
Structure of Nek2 bound to aminopyrazine compound 14
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | SERINE/THREONINE-PROTEIN KINASE NEK2 | polymer | 279 | 32662.5 | 1 | UniProt (P51955) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | NEK2, NEVER IN MITOSIS A-RELATED KINASE 2, NIMA-RELATED PROTEIN KINASE 2, NIMA-LIKE PROTEIN KINASE 1, HSPK 21 |
| 2 | B (A) | 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-methylbenzoic acid | non-polymer | 395.4 | 1 | Chemie (4VQ) | |||
| 3 | C, D, E, F (A) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 4 | G (A) | water | water | 18.0 | 74 | Chemie (HOH) |
Sequence modifications
A: 1 - 271 (UniProt: P51955)
| PDB | External Database | Details |
|---|---|---|
| Leu 272 | - | expression tag |
| Glu 273 | - | expression tag |
| His 274 | - | expression tag |
| His 275 | - | expression tag |
| His 276 | - | expression tag |
| His 277 | - | expression tag |
| His 278 | - | expression tag |
| His 279 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32662.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 537.2 | |
| All* | Total formula weight | 33199.7 |
