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2XNP

Structure of Nek2 bound to CCT244858

Summary for 2XNP
Entry DOI10.2210/pdb2xnp/pdb
Related2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO
DescriptorSERINE/THREONINE-PROTEIN KINASE NEK2, 4-{5-[(1-METHYLPIPERIDIN-4-YL)OXY]-1H-BENZIMIDAZOL-1-YL}-2-{(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY}BENZAMIDE, CHLORIDE ION, ... (5 entities in total)
Functional Keywordstransferase, centrosome, mitosis, cell cycle
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus. Isoform 1: Nucleus, nucleolus. Isoform 2: Cytoplasm: P51955
Total number of polymer chains1
Total formula weight33653.19
Authors
Mas-Droux, C.,Bayliss, R. (deposition date: 2010-08-05, release date: 2011-03-30, Last modification date: 2023-12-20)
Primary citationSolanki, S.,Innocenti, P.,Mas-Droux, C.,Boxall, K.,Barillari, C.,Van Montfort, R.L.,Aherne, G.W.,Bayliss, R.,Hoelder, S.
Benzimidazole Inhibitors Induce a Dfg-Out Conformation of Never in Mitosis Gene A-Related Kinase 2 (Nek2) without Binding to the Back Pocket and Reveal a Nonlinear Structure-Activity Relationship.
J.Med.Chem., 54:1626-, 2011
Cited by
PubMed: 21366329
DOI: 10.1021/JM1011726
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.98 Å)
Structure validation

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