2XKE

Structure of Nek2 bound to Aminipyrazine Compound 5

Summary for 2XKE

Entry DOI	10.2210/pdb2xke/pdb
Related	2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKF
Descriptor	SERINE/THREONINE-PROTEIN KINASE NEK2, 1-[3-amino-6-(3-methoxyphenyl)pyrazin-2-yl]piperidine-4-carboxylic acid, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	transferase, centrosome, mitosis
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus. Isoform 1: Nucleus, nucleolus. Isoform 2: Cytoplasm: P51955
Total number of polymer chains	1
Total formula weight	33132.66
Authors	Mas-Droux, C.,Bayliss, R. (deposition date: 2010-07-07, release date: 2010-11-03, Last modification date: 2023-12-20)
Primary citation	Whelligan, D.K.,Solanki, S.,Taylor, D.,Thomson, D.W.,Cheung, K.M.,Boxall, K.,Mas-Droux, C.,Barillari, C.,Burns, S.,Grummitt, C.G.,Collins, I.,Van Montfort, R.L.,Aherne, G.W.,Bayliss, R.,Hoelder, S. Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: Sar and Structural Characterization. J.Med.Chem., 53:7682-, 2010 Cited by PubMed: 20936789 DOI: 10.1021/JM1008727 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.203 Å)

Structure validation