2XI3
HCV-H77 NS5B Polymerase Complexed With GTP
Summary for 2XI3
Entry DOI | 10.2210/pdb2xi3/pdb |
Related | 1A1R 1A1V 1CWX 1HEI 1JR6 1N1L 1ONB 1R7C 1R7D 1R7E 1R7F 1R7G 1RGQ 2XI2 |
Descriptor | RNA-directed RNA polymerase, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | transferase, nonstructural protein, replication, rdrp, de novo priming, hepacivirus |
Biological source | Hepatitis C virus (isolate H77) |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P27958 |
Total number of polymer chains | 2 |
Total formula weight | 130309.73 |
Authors | Harrus, D.,Ahmed-El-Sayed, N.,Simister, P.C.,Miller, S.,Triconnet, M.,Hagedorn, C.H.,Mahias, K.,Rey, F.A.,Astier-Gin, T.,Bressanelli, S. (deposition date: 2010-06-25, release date: 2010-08-04, Last modification date: 2024-03-27) |
Primary citation | Harrus, D.,Ahmed-El-Sayed, N.,Simister, P.C.,Miller, S.,Triconnet, M.,Hagedorn, C.H.,Mahias, K.,Rey, F.A.,Astier-Gin, T.,Bressanelli, S. Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis J.Biol.Chem., 285:32906-, 2010 Cited by PubMed: 20729191DOI: 10.1074/JBC.M110.151316 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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