2XI3

HCV-H77 NS5B Polymerase Complexed With GTP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	RNA-directed RNA polymerase	polymer	576	63786.2	2	UniProt (P27958) Pfam (PF00998)	Hepatitis C virus (isolate H77)	NS5B,p68
2	C, D, E, I, J (A, B)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	5	Chemie (GTP)
3	F, G, H, K, L (A, B)	MAGNESIUM ION	non-polymer		24.3	5	Chemie (MG)
4	M, N (A, B)	water	water		18.0	792	Chemie (HOH)

Sequence modifications

A, B: 1 - 570 (UniProt: P27958)

PDB	External Database	Details
Gln 49	Lys 2469	conflict
His 65	Gln 2485	conflict
Thr 92	Ala 2512	conflict
Phe 217	Leu 2637	conflict
Gly 283	Arg 2703	conflict
Cys 295	Arg 2715	conflict
Arg 505	Trp 2925	conflict
Ser 513	Ala 2933	conflict
Arg 517	Lys 2937	conflict
Ala 540	Thr 2960	conflict
His 571	-	expression tag
His 572	-	expression tag
His 573	-	expression tag
His 574	-	expression tag
His 575	-	expression tag
His 576	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	127572.3
Non-Polymers*	Number of molecules	10
	Total formula weight	2737.4
All*	Total formula weight	130309.7

*Water molecules are not included.