2XI3
HCV-H77 NS5B Polymerase Complexed With GTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | RNA-directed RNA polymerase | polymer | 576 | 63786.2 | 2 | UniProt (P27958) Pfam (PF00998) | Hepatitis C virus (isolate H77) | NS5B,p68 |
| 2 | C, D, E, I, J (A, B) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 5 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 3 | F, G, H, K, L (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) PubChem (888) | |||
| 4 | M, N (A, B) | water | water | 18.0 | 792 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 570 (UniProt: P27958)
| PDB | External Database | Details |
|---|---|---|
| Gln 49 | Lys 2469 | conflict |
| His 65 | Gln 2485 | conflict |
| Thr 92 | Ala 2512 | conflict |
| Phe 217 | Leu 2637 | conflict |
| Gly 283 | Arg 2703 | conflict |
| Cys 295 | Arg 2715 | conflict |
| Arg 505 | Trp 2925 | conflict |
| Ser 513 | Ala 2933 | conflict |
| Arg 517 | Lys 2937 | conflict |
| Ala 540 | Thr 2960 | conflict |
| His 571 | - | expression tag |
| His 572 | - | expression tag |
| His 573 | - | expression tag |
| His 574 | - | expression tag |
| His 575 | - | expression tag |
| His 576 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 127572.3 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2737.4 | |
| All* | Total formula weight | 130309.7 |
