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2XI3

HCV-H77 NS5B Polymerase Complexed With GTP

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues22
DetailsBINDING SITE FOR RESIDUE GTP A 1001
ChainResidue
ALYS141
ATHR390
AARG394
AGLU446
ASER556
AGLY557
AGTP1002
AMG1004
AHOH2230
AHOH2281
AHOH2391
AGLU143
AHOH2393
AHOH2394
AHOH2395
APHE145
AARG158
AILE160
ASER282
ATHR287
ASER367
AARG386

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE GTP A 1002
ChainResidue
AARG48
ALYS51
ALYS141
AARG158
AASP220
AASP225
ASER282
AASP318
AGTP1001
AMG1005
AHOH2145
AHOH2395
AHOH2396

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GTP A 1003
ChainResidue
ALYS69
AGLU70
AALA73
AALA74
ALYS77
BCYS110
BALA112

site_idAC4
Number of Residues20
DetailsBINDING SITE FOR RESIDUE GTP B 1001
ChainResidue
BLYS141
BGLU143
BARG158
BSER282
BTHR287
BSER367
BARG386
BTHR390
BARG394
BGLU446
BSER556
BGLY557
BGTP1002
BMG1005
BHOH2233
BHOH2390
BHOH2391
BHOH2392
BHOH2393
BHOH2394

site_idAC5
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GTP B 1002
ChainResidue
BARG48
BLYS141
BARG158
BASP220
BASP225
BSER282
BASP318
BGTP1001
BMG1006
BHOH2395
BHOH2396

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 1004
ChainResidue
AGTP1001
AHOH2281
AHOH2394
AHOH2396

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 1005
ChainResidue
AASP220
ATHR221
AGTP1002
AHOH2187
AHOH2242

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 1006
ChainResidue
ATYR358
AASP359
BASP437
BARG514
BHOH2369

site_idAC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG B 1005
ChainResidue
BARG158
BGTP1001
BHOH2393
BHOH2394

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG B 1006
ChainResidue
BASP220
BTHR221
BGTP1002
BHOH2247

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P26663
ChainResidueDetails
AASP220
AASP318
AASP319
BASP220
BASP318
BASP319

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ASER29
ASER42
BSER29
BSER42

Catalytic Information from CSA
site_idMCSA1
Number of Residues
DetailsM-CSA 776
ChainResidueDetails

site_idMCSA2
Number of Residues
DetailsM-CSA 776
ChainResidueDetails

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PDB entries from 2024-10-30

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