1R7D

NMR structure of the membrane anchor domain (1-31) of the nonstructural protein 5A (NS5A) of hepatitis C virus (Ensemble of 51 structures, sample in 50% tfe)

Summary for 1R7D
Related1R7C 1R7E 1R7F 1R7G
NMR InformationBMRB: 5978
DescriptorGenome polyprotein (1 entity in total)
Functional Keywordsmembrane anchor domain, hcv ns5a protein, peptide., membrane protein
Cellular locationCore protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P27958
Total number of polymer chains1
Total formula weight3770.42
Authors
Penin, F.,Brass, V.,Appel, N.,Ramboarina, S.,Montserret, R.,Ficheux, D.,Blum, H.E.,Bartenschlager, R.,Moradpour, D. (deposition date: 2003-10-21, release date: 2004-08-10, Last modification date: 2011-07-13)
Primary citationAppel, N.,Bartenschlager, R.,Blum, H.E.,Brass, V.,Ficheux, D.,Montserret, R.,Moradpour, D.,Penin, F.,Ramboarina, S.
Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A.
J.Biol.Chem., 279:40835-40843, 2004
PubMed: 15247283
DOI: 110.1074/jbc.M404761200
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation
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PDB entries from 2021-06-16