2XCR
The 3.5A crystal structure of the catalytic core (B'A' region) of Staphylococcus aureus DNA Gyrase complexed with GSK299423 and DNA
Summary for 2XCR
Entry DOI | 10.2210/pdb2xcr/pdb |
Related | 2XCO 2XCQ 2XCS 2XCT |
Descriptor | DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A, 5'-D(*5UA*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP *GP*CP*TP)-3', 5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP *GP*CP*TP)-3', ... (4 entities in total) |
Functional Keywords | isomerase |
Biological source | STAPHYLOCOCCUS AUREUS More |
Cellular location | Cytoplasm (Potential): Q99XG5 |
Total number of polymer chains | 8 |
Total formula weight | 354710.63 |
Authors | Bax, B.D.,Chan, P.F.,Eggleston, D.S.,Fosberry, A.,Gentry, D.R.,Gorrec, F.,Giordano, I.,Hann, M.M.,Hennessy, A.,Hibbs, M.,Huang, J.,Jones, E.,Jones, J.,Brown, K.K.,Lewis, C.J.,May, E.W.,Singh, O.,Spitzfaden, C.,Shen, C.,Shillings, A.,Theobald, A.F.,Wohlkonig, A.,Pearson, N.D.,Gwynn, M.N. (deposition date: 2010-04-25, release date: 2010-08-04, Last modification date: 2024-05-08) |
Primary citation | Bax, B.D.,Chan, P.F.,Eggleston, D.S.,Fosberry, A.,Gentry, D.R.,Gorrec, F.,Giordano, I.,Hann, M.M.,Hennessy, A.,Hibbs, M.,Huang, J.,Jones, E.,Jones, J.,Brown, K.K.,Lewis, C.J.,May, E.W.,Saunders, M.R.,Singh, O.,Spitzfaden, C.,Shen, C.,Shillings, A.,Theobald, A.F.,Wohlkonig, A.,Pearson, N.D.,Gwynn, M.N. Type Iia Topoisomerase Inhibition by a New Class of Antibacterial Agents. Nature, 466:935-, 2010 Cited by PubMed: 20686482DOI: 10.1038/NATURE09197 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
Download full validation report