2XCR

The 3.5A crystal structure of the catalytic core (B'A' region) of Staphylococcus aureus DNA Gyrase complexed with GSK299423 and DNA

Summary for 2XCR

• Entry DOI: 10.2210/pdb2xcr/pdb
• Related: 2XCO 2XCQ 2XCS 2XCT
• Descriptor: DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A, 5'-D(*5UA*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP *GP*CP*TP)-3', 5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP *GP*CP*TP)-3', ... (4 entities in total)
• Functional Keywords: isomerase
• Biological source: STAPHYLOCOCCUS AUREUS; More
• Cellular location: Cytoplasm (Potential): Q99XG5
• Total number of polymer chains: 8
• Total formula weight: 354710.63

Authors

Bax, B.D.,Chan, P.F.,Eggleston, D.S.,Fosberry, A.,Gentry, D.R.,Gorrec, F.,Giordano, I.,Hann, M.M.,Hennessy, A.,Hibbs, M.,Huang, J.,Jones, E.,Jones, J.,Brown, K.K.,Lewis, C.J.,May, E.W.,Singh, O.,Spitzfaden, C.,Shen, C.,Shillings, A.,Theobald, A.F.,Wohlkonig, A.,Pearson, N.D.,Gwynn, M.N. (deposition date: 2010-04-25, release date: 2010-08-04, Last modification date: 2024-05-08)

• Primary citation: Bax, B.D.,Chan, P.F.,Eggleston, D.S.,Fosberry, A.,Gentry, D.R.,Gorrec, F.,Giordano, I.,Hann, M.M.,Hennessy, A.,Hibbs, M.,Huang, J.,Jones, E.,Jones, J.,Brown, K.K.,Lewis, C.J.,May, E.W.,Saunders, M.R.,Singh, O.,Spitzfaden, C.,Shen, C.,Shillings, A.,Theobald, A.F.,Wohlkonig, A.,Pearson, N.D.,Gwynn, M.N.; Type Iia Topoisomerase Inhibition by a New Class of Antibacterial Agents.; Nature, 466:935-, 2010; PubMed: 20686482; DOI: 10.1038/NATURE09197

Experimental method

X-RAY DIFFRACTION (3.5 Å)