Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006259 | biological_process | DNA metabolic process |
| B | 0006265 | biological_process | DNA topological change |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006259 | biological_process | DNA metabolic process |
| D | 0006265 | biological_process | DNA topological change |
| S | 0003677 | molecular_function | DNA binding |
| S | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| S | 0005524 | molecular_function | ATP binding |
| S | 0006259 | biological_process | DNA metabolic process |
| S | 0006265 | biological_process | DNA topological change |
| U | 0003677 | molecular_function | DNA binding |
| U | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| U | 0005524 | molecular_function | ATP binding |
| U | 0006259 | biological_process | DNA metabolic process |
| U | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE RXV E 1021 |
| Chain | Residue |
| B | ALA1068 |
| F | DC11 |
| B | ASP1083 |
| D | ALA1068 |
| D | GLY1072 |
| D | ASP1083 |
| D | MET1121 |
| E | DG10 |
| E | DC11 |
| F | DG10 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE RXV W 1020 |
| Chain | Residue |
| S | ALA1068 |
| S | GLY1072 |
| S | MET1075 |
| S | ASP1083 |
| U | ALA1068 |
| U | ASP1083 |
| V | DG10 |
| V | DC11 |
| W | DG10 |
| W | DC11 |
Functional Information from PROSITE/UniProt
| site_id | PS00177 |
| Number of Residues | 9 |
| Details | TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG |
| Chain | Residue | Details |
| B | LEU433-GLY441 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 456 |
| Details | Domain: {"description":"Toprim","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01897","evidenceCode":"ECO:0000255"}]} |
