2XCS
The 2.1A crystal structure of S. aureus Gyrase complex with GSK299423 and DNA
Summary for 2XCS
Entry DOI | 10.2210/pdb2xcs/pdb |
Related | 2XCO 2XCQ 2XCR 2XCT |
Descriptor | DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A, 5'-5UA*D(GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP *CP*TP*AP*CP*GP*GP*CP*T)-3', MANGANESE (II) ION, ... (5 entities in total) |
Functional Keywords | isomerase, type iia topoisomerase |
Biological source | STAPHYLOCOCCUS AUREUS More |
Cellular location | Cytoplasm (Potential): Q99XG5 |
Total number of polymer chains | 4 |
Total formula weight | 169099.30 |
Authors | Bax, B.D.,Chan, P.F.,Eggleston, D.S.,Fosberry, A.,Gentry, D.R.,Gorrec, F.,Giordano, I.,Hann, M.M.,Hennessy, A.,Hibbs, M.,Huang, J.,Jones, E.,Jones, J.,Brown, K.K.,Lewis, C.J.,May, E.W.,Singh, O.,Spitzfaden, C.,Shen, C.,Shillings, A.,Theobald, A.F.,Wohlkonig, A.,Pearson, N.D.,Gwynn, M.N. (deposition date: 2010-04-25, release date: 2010-08-04, Last modification date: 2023-12-20) |
Primary citation | Bax, B.D.,Chan, P.F.,Eggleston, D.S.,Fosberry, A.,Gentry, D.R.,Gorrec, F.,Giordano, I.,Hann, M.M.,Hennessy, A.,Hibbs, M.,Huang, J.,Jones, E.,Jones, J.,Brown, K.K.,Lewis, C.J.,May, E.W.,Saunders, M.R.,Singh, O.,Spitzfaden, C.,Shen, C.,Shillings, A.,Theobald, A.F.,Wohlkonig, A.,Pearson, N.D.,Gwynn, M.N. Type Iia Topoisomerase Inhibition by a New Class of Antibacterial Agents. Nature, 466:935-, 2010 Cited by PubMed: 20686482DOI: 10.1038/NATURE09197 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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