2XCT

The twinned 3.35A structure of S. aureus Gyrase complex with Ciprofloxacin and DNA

Summary for 2XCT

• Entry DOI: 10.2210/pdb2xct/pdb
• Related: 2XCO 2XCQ 2XCR 2XCS
• Descriptor: DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A, 5'-D(TP*GP*TP*GP*CP*GP*GP*T)-3', 5'-D(AP*GP*CP*CP*GP*TP*AP*G)-3', ... (7 entities in total)
• Functional Keywords: isomerase-dna-antibiotic complex, isomerase/dna/antibiotic
• Biological source: STAPHYLOCOCCUS AUREUS; More
• Cellular location: Cytoplasm (Potential): Q99XG5
• Total number of polymer chains: 12
• Total formula weight: 338530.89

Authors

Bax, B.D.,Chan, P.,Eggleston, D.S.,Fosberry, A.,Gentry, D.R.,Gorrec, F.,Giordano, I.,Hann, M.M.,Hennessy, A.,Hibbs, M.,Huang, J.,Jones, E.,Jones, J.,Brown, K.K.,Lewis, C.J.,May, E.,Singh, O.,Spitzfaden, C.,Shen, C.,Shillings, A.,Theobald, A.,Wohlkonig, A.,Pearson, N.D.,Gwynn, M.N. (deposition date: 2010-04-25, release date: 2010-08-25, Last modification date: 2011-07-13)

• Primary citation: Bax, B.D.,Chan, P.F.,Eggleston, D.S.,Fosberry, A.,Gentry, D.R.,Gorrec, F.,Giordano, I.,Hann, M.M.,Hennessy, A.,Hibbs, M.,Huang, J.,Jones, E.,Jones, J.,Brown, K.K.,Lewis, C.J.,May, E.W.,Saunders, M.R.,Singh, O.,Spitzfaden, C.,Shen, C.,Shillings, A.,Theobald, A.F.,Wohlkonig, A.,Pearson, N.D.,Gwynn, M.N.; Type Iia Topoisomerase Inhibition by a New Class of Antibacterial Agents.; Nature, 466:935-, 2010; PubMed: 20686482; DOI: 10.1038/NATURE09197

Experimental method

X-RAY DIFFRACTION (3.35 Å)