2WII

Complement C3b in complex with factor H domains 1-4

2WII の概要

• エントリーDOI: 10.2210/pdb2wii/pdb
• 関連するPDBエントリー: 1FHC 1HFH 1OJV 2A73 2A74 2G7I 2ICF 2JGW 2JGX 2RLP 2RLQ 2V8E 2W80 2W81
• 分子名称: COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT FACTOR H, ... (8 entities in total)
• 機能のキーワード: immune system, sushi, secreted, polymorphism, glycoprotein, complement system, complement pathway, immune response, innate immunity, disease mutation, inflammatory response, complement alternate pathway, cleavage on pair of basic residues, age-related macular degeneration, regulator of complement activation, alternative pathway, alternative splicing, phosphoprotein, disulfide bond, thioester bond
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Secreted: P01024 P01024
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 209591.19

構造登録者

Wu, J.,Janssen, B.J.C.,Gros, P. (登録日: 2009-05-12, 公開日: 2009-06-09, 最終更新日: 2023-12-13)

• 主引用文献: Wu, J.,Wu, Y.Q.,Ricklin, D.,Janssen, B.J.,Lambris, J.D.,Gros, P.; Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.; Nat. Immunol., 10:728-733, 2009; PubMed: 19503104; DOI: 10.1038/ni.1755

実験手法

X-RAY DIFFRACTION (2.7 Å)