2WHO
CRYSTAL STRUCTURE OF HEPATITIS C VIRUS NS5B POLYMERASE FROM 1B GENOTYPE IN COMPLEX WITH A NON-NUCLEOSIDE INHIBITOR
Summary for 2WHO
Entry DOI | 10.2210/pdb2who/pdb |
Related | 1A1Q 1BT7 1C2P 1CSJ 1CU1 1GX5 1GX6 1JXP 1NHU 1NHV 1NS3 1OS5 1QUV 2AWZ 2AX0 2AX1 2BRK 2BRL 2I1R 2JC0 2JC1 2WCX 8OHM |
Descriptor | RNA-DIRECTED RNA POLYMERASE, MANGANESE (II) ION, 2-(3-bromophenyl)-6-[(2-hydroxyethyl)amino]-1h-benzo[de]isoquinoline-1,3(2h)-dione, ... (4 entities in total) |
Functional Keywords | transferase, rna replication, envelope protein, hepatitis c virus, endoplasmic reticulum, non nucleoside inhibitor, viral protein, metal-binding, transmembrane, polymerase, atp-binding, genotype 1b, rna-binding, rna-dependent rna polymerase, nni, hcv, ns5b, membrane, helicase, hydrolase, nucleotide-binding, allosteric inhibitor, rna-directed rna polymerase |
Biological source | HEPATITIS C VIRUS |
Total number of polymer chains | 2 |
Total formula weight | 120325.27 |
Authors | Di Marco, S. (deposition date: 2009-05-05, release date: 2009-08-11, Last modification date: 2023-12-13) |
Primary citation | Ontoria, J.M.,Rydberg, E.H.,Di Marco, S.,Tomei, L.,Attenni, B.,Malancona, S.,Martin Hernando, J.I.,Gennari, N.,Koch, U.,Narjes, F.,Rowley, M.,Summa, V.,Carroll, S.S.,Olsen, D.B.,De Francesco, R.,Altamura, S.,Migliaccio, G.,Carfi, A. Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors. J. Med. Chem., 52:5217-5227, 2009 Cited by PubMed: 19877603DOI: 10.1021/jm900517t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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