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2WHO

CRYSTAL STRUCTURE OF HEPATITIS C VIRUS NS5B POLYMERASE FROM 1B GENOTYPE IN COMPLEX WITH A NON-NUCLEOSIDE INHIBITOR

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-directed RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-directed RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN A 1532
ChainResidue
AASP220
AASP318
AASP319
AMN1533
AHOH2254
AHOH2255
AHOH2256

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN A 1533
ChainResidue
AASP318
AMN1532
AHOH2254
AHOH2257
AHOH2258
AASP220
ATHR221

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN B 1532
ChainResidue
BASP220
BASP318
BASP319
BMN1533
BHOH2257

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN B 1533
ChainResidue
BASP220
BTHR221
BASP318
BMN1532
BHOH2257
BHOH2258
BHOH2259

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE VGI B 1534
ChainResidue
BARG422
BMET423
BLEU474
BHIS475
BARG501
BTRP528
BHOH2260

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE VGI A 1534
ChainResidue
AARG422
AMET423
ALEU474
AALA486
AARG501
ATRP528
AHOH2259

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues236
DetailsDomain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10557268","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11884572","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"UniProtKB","id":"P26662","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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