2WHO

CRYSTAL STRUCTURE OF HEPATITIS C VIRUS NS5B POLYMERASE FROM 1B GENOTYPE IN COMPLEX WITH A NON-NUCLEOSIDE INHIBITOR

Summary for 2WHO

• Entry DOI: 10.2210/pdb2who/pdb
• Related: 1A1Q 1BT7 1C2P 1CSJ 1CU1 1GX5 1GX6 1JXP 1NHU 1NHV 1NS3 1OS5 1QUV 2AWZ 2AX0 2AX1 2BRK 2BRL 2I1R 2JC0 2JC1 2WCX 8OHM
• Descriptor: RNA-DIRECTED RNA POLYMERASE, MANGANESE (II) ION, 2-(3-bromophenyl)-6-[(2-hydroxyethyl)amino]-1h-benzo[de]isoquinoline-1,3(2h)-dione, ... (4 entities in total)
• Functional Keywords: transferase, rna replication, envelope protein, hepatitis c virus, endoplasmic reticulum, non nucleoside inhibitor, viral protein, metal-binding, transmembrane, polymerase, atp-binding, genotype 1b, rna-binding, rna-dependent rna polymerase, nni, hcv, ns5b, membrane, helicase, hydrolase, nucleotide-binding, allosteric inhibitor, rna-directed rna polymerase
• Biological source: HEPATITIS C VIRUS
• Total number of polymer chains: 2
• Total formula weight: 120325.27

Authors

Di Marco, S. (deposition date: 2009-05-05, release date: 2009-08-11, Last modification date: 2023-12-13)

• Primary citation: Ontoria, J.M.,Rydberg, E.H.,Di Marco, S.,Tomei, L.,Attenni, B.,Malancona, S.,Martin Hernando, J.I.,Gennari, N.,Koch, U.,Narjes, F.,Rowley, M.,Summa, V.,Carroll, S.S.,Olsen, D.B.,De Francesco, R.,Altamura, S.,Migliaccio, G.,Carfi, A.; Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors.; J. Med. Chem., 52:5217-5227, 2009; PubMed: 19877603; DOI: 10.1021/jm900517t

Experimental method

X-RAY DIFFRACTION (2 Å)