2WHO
CRYSTAL STRUCTURE OF HEPATITIS C VIRUS NS5B POLYMERASE FROM 1B GENOTYPE IN COMPLEX WITH A NON-NUCLEOSIDE INHIBITOR
2WHO の概要
エントリーDOI | 10.2210/pdb2who/pdb |
関連するPDBエントリー | 1A1Q 1BT7 1C2P 1CSJ 1CU1 1GX5 1GX6 1JXP 1NHU 1NHV 1NS3 1OS5 1QUV 2AWZ 2AX0 2AX1 2BRK 2BRL 2I1R 2JC0 2JC1 2WCX 8OHM |
分子名称 | RNA-DIRECTED RNA POLYMERASE, MANGANESE (II) ION, 2-(3-bromophenyl)-6-[(2-hydroxyethyl)amino]-1h-benzo[de]isoquinoline-1,3(2h)-dione, ... (4 entities in total) |
機能のキーワード | transferase, rna replication, envelope protein, hepatitis c virus, endoplasmic reticulum, non nucleoside inhibitor, viral protein, metal-binding, transmembrane, polymerase, atp-binding, genotype 1b, rna-binding, rna-dependent rna polymerase, nni, hcv, ns5b, membrane, helicase, hydrolase, nucleotide-binding, allosteric inhibitor, rna-directed rna polymerase |
由来する生物種 | HEPATITIS C VIRUS |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 120325.27 |
構造登録者 | |
主引用文献 | Ontoria, J.M.,Rydberg, E.H.,Di Marco, S.,Tomei, L.,Attenni, B.,Malancona, S.,Martin Hernando, J.I.,Gennari, N.,Koch, U.,Narjes, F.,Rowley, M.,Summa, V.,Carroll, S.S.,Olsen, D.B.,De Francesco, R.,Altamura, S.,Migliaccio, G.,Carfi, A. Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors. J. Med. Chem., 52:5217-5227, 2009 Cited by PubMed: 19877603DOI: 10.1021/jm900517t 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
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