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2VPP

Drosophila melanogaster deoxyribonucleoside kinase successfully activates gemcitabine in transduced cancer cell lines

Summary for 2VPP
Entry DOI10.2210/pdb2vpp/pdb
Related1J90 1OE0 1OT3 1ZM7 1ZMX 2JCS 2VP0 2VP2 2VP4 2VP5 2VP6 2VP9
DescriptorDEOXYNUCLEOSIDE KINASE, GEMCITABINE, SULFATE ION, ... (4 entities in total)
Functional Keywordskinase, cancer, transferase, atp-binding, phosphoprotein, nucleoside analogs, nucleotide-binding, structure-function relationship, gemcitabine, gene therapy, dna synthesis
Biological sourceDROSOPHILA MELANOGASTER (FRUIT FLY)
Total number of polymer chains2
Total formula weight54531.94
Authors
Knecht, W.,Mikkelsen, N.E.,Clausen, A.,Willer, M.,Gojkovic, Z.,Piskur, J. (deposition date: 2008-03-03, release date: 2009-03-24, Last modification date: 2023-12-13)
Primary citationKnecht, W.,Mikkelsen, N.E.,Clausen, A.,Willer, M.,Eklund, H.,Gojkovic, Z.,Piskur, J.
Drosophila Melanogaster Deoxyribonucleoside Kinase Activates Gemcitabine.
Biochem.Biophys.Res.Commun., 382:430-, 2009
Cited by
PubMed: 19285960
DOI: 10.1016/J.BBRC.2009.03.041
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

217705

数据于2024-03-27公开中

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