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2VPP

Drosophila melanogaster deoxyribonucleoside kinase successfully activates gemcitabine in transduced cancer cell lines

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004136molecular_functiondeoxyadenosine kinase activity
A0004137molecular_functiondeoxycytidine kinase activity
A0004138molecular_functiondeoxyguanosine kinase activity
A0004797molecular_functionthymidine kinase activity
A0004849molecular_functionuridine kinase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0006139biological_processnucleobase-containing compound metabolic process
A0006170biological_processdAMP biosynthetic process
A0006222biological_processUMP biosynthetic process
A0009157biological_processdeoxyribonucleoside monophosphate biosynthetic process
A0009224biological_processCMP biosynthetic process
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0019136molecular_functiondeoxynucleoside kinase activity
A0043174biological_processnucleoside salvage
A0043771molecular_functioncytidine kinase activity
A0071897biological_processDNA biosynthetic process
A1901293biological_processnucleoside phosphate biosynthetic process
B0000166molecular_functionnucleotide binding
B0004136molecular_functiondeoxyadenosine kinase activity
B0004137molecular_functiondeoxycytidine kinase activity
B0004138molecular_functiondeoxyguanosine kinase activity
B0004797molecular_functionthymidine kinase activity
B0004849molecular_functionuridine kinase activity
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0006139biological_processnucleobase-containing compound metabolic process
B0006170biological_processdAMP biosynthetic process
B0006222biological_processUMP biosynthetic process
B0009157biological_processdeoxyribonucleoside monophosphate biosynthetic process
B0009224biological_processCMP biosynthetic process
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0019136molecular_functiondeoxynucleoside kinase activity
B0043174biological_processnucleoside salvage
B0043771molecular_functioncytidine kinase activity
B0071897biological_processDNA biosynthetic process
B1901293biological_processnucleoside phosphate biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE GEO A 1210
ChainResidue
AILE29
AALA110
APHE114
AGLU172
AHOH2050
AHOH2071
AHOH2119
AHOH2137
AGLU52
ATRP57
AMET69
ATYR70
APHE80
AGLN81
AVAL84
AARG105

site_idAC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE GEO B 1207
ChainResidue
BILE29
BGLU52
BTRP57
BMET69
BTYR70
BPHE80
BGLN81
BVAL84
BARG105
BALA110
BPHE114
BGLU172
BHOH2040
BHOH2088
BHOH2100

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 1211
ChainResidue
AGLY30
ASER31
AGLY32
ALYS33
ATHR34
AARG167
AHOH2137
AHOH2138

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE SO4 B 1208
ChainResidue
BASN28
BGLY30
BSER31
BGLY32
BLYS33
BTHR34
BARG167
BHOH2099
BHOH2100
BHOH2101

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255
ChainResidueDetails
AGLU104
BGLU104

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLY27
BGLY27

site_idSWS_FT_FI3
Number of Residues10
DetailsBINDING:
ChainResidueDetails
AGLU52
BGLU172
ATYR70
AGLN81
AARG105
AGLU172
BGLU52
BTYR70
BGLN81
BARG105

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1kim
ChainResidueDetails
AGLY30
AARG169
AGLU52
AARG105

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1kim
ChainResidueDetails
BGLY30
BGLU52
BARG105

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1kim
ChainResidueDetails
AGLU52
AARG105

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1kim
ChainResidueDetails
BGLU52
BARG105

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PDB entries from 2025-06-11

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