2VI5

LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO N-6-(ribitylamino)pyrimidine-2,4(1H,3H)-dione-5-yl-propionamide

2VI5 の概要

• エントリーDOI: 10.2210/pdb2vi5/pdb
• 関連するPDBエントリー: 1W19 1W29 2C92 2C94 2C97 2C9B 2C9D
• 分子名称: 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE, 1-deoxy-1-{[(5S)-2,6-dioxo-5-(propanoylamino)-1,2,5,6-tetrahydropyrimidin-4-yl]amino}-D-ribitol, POTASSIUM ION, ... (5 entities in total)
• 機能のキーワード: transferase, lumazine synthase, riboflavin biosynthesis, mycobacterium tuberculosis
• 由来する生物種: MYCOBACTERIUM TUBERCULOSIS
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 168734.87

構造登録者

Morgunova, E.,Zhang, Y.,Jin, G.,Illarionov, B.,Bacher, A.,Fischer, M.,Cushman, M.,Ladenstein, R. (登録日: 2007-11-27, 公開日: 2008-04-08, 最終更新日: 2023-12-13)

• 主引用文献: Zhang, Y.,Illarionov, B.,Morgunova, E.,Bacher, A.,Fischer, M.,Ladenstein, R.,Cushman, M.; A New Series of N-[2,4-Dioxo-6-D-Ribitylamino-1,2, 3,4-Tetrahydropyrimidin-5-Yl]Oxalamic Acid Derivatives as Inhibitors of Lumazine Syntase and Riboflavin Synthase: Design, Synthesis, Biochemical Evaluation, Crystallography and Mechanistic Implications.; J.Org.Chem., 73:2715-, 2008; PubMed: 18331058; DOI: 10.1021/JO702631A

実験手法

X-RAY DIFFRACTION (2.3 Å)