2C97

LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 4-(6- chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)butyl phosphate

Summary for 2C97

• Entry DOI: 10.2210/pdb2c97/pdb
• Related: 1W19 1W29 2C92 2C94 2C9B 2C9D
• Descriptor: 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE, 4-(6-CHLORO-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL) BUTYL PHOSPHATE, POTASSIUM ION, ... (7 entities in total)
• Functional Keywords: transferase, riboflavin biosynthesis, inhibitor binding
• Biological source: MYCOBACTERIUM TUBERCULOSIS
• Total number of polymer chains: 5
• Total formula weight: 85212.95

Authors

Morgunova, E.,Illarionov, B.,Jin, G.,Haase, I.,Fischer, M.,Cushman, M.,Bacher, A.,Ladenstein, R. (deposition date: 2005-12-09, release date: 2006-12-13, Last modification date: 2023-12-13)

• Primary citation: Morgunova, E.,Illarionov, B.,Sambaiah, T.,Haase, I.,Bacher, A.,Cushman, M.,Fischer, M.,Ladenstein, R.; Structural and Thermodynamic Insights Into the Binding Mode of Five Novel Inhibitors of Lumazine Synthase from Mycobacterium Tuberculosis.; FEBS J., 273:4790-, 2006; PubMed: 16984393; DOI: 10.1111/J.1742-4658.2006.05481.X

Experimental method

X-RAY DIFFRACTION (2 Å)