1W19

Lumazine Synthase from Mycobacterium tuberculosis bound to 3-(1,3,7- trihydro-9-D-ribityl-2,6,8-purinetrione-7-yl)propane 1-phosphate

Summary for 1W19

• Entry DOI: 10.2210/pdb1w19/pdb
• Descriptor: 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE, (4S,5S)-1,2-DITHIANE-4,5-DIOL, ACETIC ACID, ... (11 entities in total)
• Functional Keywords: transferase, riboflavin biosynthesis, lumazine synthase, inhibitor binding
• Biological source: MYCOBACTERIUM TUBERCULOSIS
• Total number of polymer chains: 5
• Total formula weight: 85871.32

Authors

Morgunova, E.,Meining, W.,Illarionov, B.,Haase, I.,Fischer, M.,Cushman, M.,Bacher, A.,Ladenstein, R. (deposition date: 2004-06-03, release date: 2005-03-02, Last modification date: 2023-12-13)

• Primary citation: Morgunova, E.,Meining, W.,Illarionov, B.,Haase, I.,Jin, G.,Bacher, A.,Cushman, M.,Fischer, M.,Ladenstein, R.; Crystal Structure of Lumazine Synthase from Mycobacterium Tuberculosis as a Target for Rational Drug Design: Binding Mode of a New Class of Purinetrione Inhibitors(,); Biochemistry, 44:2746-, 2005; PubMed: 15723519; DOI: 10.1021/BI047848A

Experimental method

X-RAY DIFFRACTION (2 Å)