2VI5

LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO N-6-(ribitylamino)pyrimidine-2,4(1H,3H)-dione-5-yl-propionamide

Summary for 2VI5

Entry DOI	10.2210/pdb2vi5/pdb
Related	1W19 1W29 2C92 2C94 2C97 2C9B 2C9D
Descriptor	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE, 1-deoxy-1-{[(5S)-2,6-dioxo-5-(propanoylamino)-1,2,5,6-tetrahydropyrimidin-4-yl]amino}-D-ribitol, POTASSIUM ION, ... (5 entities in total)
Functional Keywords	transferase, lumazine synthase, riboflavin biosynthesis, mycobacterium tuberculosis
Biological source	MYCOBACTERIUM TUBERCULOSIS
Total number of polymer chains	10
Total formula weight	168734.87
Authors	Morgunova, E.,Zhang, Y.,Jin, G.,Illarionov, B.,Bacher, A.,Fischer, M.,Cushman, M.,Ladenstein, R. (deposition date: 2007-11-27, release date: 2008-04-08, Last modification date: 2023-12-13)
Primary citation	Zhang, Y.,Illarionov, B.,Morgunova, E.,Bacher, A.,Fischer, M.,Ladenstein, R.,Cushman, M. A New Series of N-[2,4-Dioxo-6-D-Ribitylamino-1,2, 3,4-Tetrahydropyrimidin-5-Yl]Oxalamic Acid Derivatives as Inhibitors of Lumazine Syntase and Riboflavin Synthase: Design, Synthesis, Biochemical Evaluation, Crystallography and Mechanistic Implications. J.Org.Chem., 73:2715-, 2008 Cited by PubMed: 18331058 DOI: 10.1021/JO702631A PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation