2V7A

Crystal structure of the T315I Abl mutant in complex with the inhibitor PHA-739358

Summary for 2V7A

Related1AB2 1JU5 2F4J 2G2F 2GQG 1ABL 1AWO 1BBZ 1OPL 1ZZP 2ABL 2FO0 2G2H
DescriptorPROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1, N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordskinase, nucleus, myristate, cytoplasm, manganese, cell adhesion, metal-binding, proto-oncogene, tyrosine-protein kinase, chromosomal rearrangement, transferase, lipoprotein, polymorphism, cytoskeleton, magnesium, sh2 domain, sh3 domain, atp-binding, nucleotide-binding, alternative splicing, phosphorylation, kinase inhibitor, t315i abl mutant
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total molecular weight67283.31
Authors
Modugno, M.,Casale, E.,Soncini, C.,Rosettani, P.,Colombo, R.,Lupi, R.,Rusconi, L.,Fancelli, D.,Carpinelli, P.,Cameron, A.D.,Isacchi, A.,Moll, J. (deposition date: 2007-07-27, release date: 2007-09-18, Last modification date: 2019-04-03)
Primary citation
Modugno, M.,Casale, E.,Soncini, C.,Rosettani, P.,Colombo, R.,Lupi, R.,Rusconi, L.,Fancelli, D.,Carpinelli, P.,Cameron, A.D.,Isacchi, A.,Moll, J.
Crystal Structure of the T315I Abl Mutant in Complex with the Aurora Kinases Inhibitor Pha-739358.
Cancer Res., 67:7987-, 2007
PubMed: 17804707 (PDB entries with the same primary citation)
DOI: 10.1158/0008-5472.CAN-07-1825
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23950 4.9% 4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2v7a
no rotation
Molmil generated image of 2v7a
rotated about x axis by 90°
Molmil generated image of 2v7a
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 2v7a
no rotation
Molmil generated image of 2v7a
rotated about x axis by 90°
Molmil generated image of 2v7a
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2v7a.pdb1.gz [49.74 KB])
Coordinate files for Biological unit (2v7a.pdb2.gz [48.94 KB])