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2V7A

Crystal structure of the T315I Abl mutant in complex with the inhibitor PHA-739358

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1polymer28633142.82UniProt (P00519)
Pfam (PF07714)
HOMO SAPIENS (HUMAN)ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1, P150, C-ABL
2C, E
(A, B)
N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDEnon-polymer474.62Chemie (627)
3D, F
(A, B)
MAGNESIUM IONnon-polymer24.32Chemie (MG)
4G, H
(A, B)
waterwater18.0166Chemie (HOH)
Sequence modifications
A, B: 227 - 228 (PDB: 2V7A)
A, B: 229 - 512 (UniProt: P00519)
PDBExternal DatabaseDetails
Ile 315Thr 315engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight66285.6
Non-Polymers*Number of molecules4
Total formula weight997.7
All*Total formula weight67283.3
*Water molecules are not included.

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PDB entries from 2024-10-30

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