2V7A
Crystal structure of the T315I Abl mutant in complex with the inhibitor PHA-739358
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 | polymer | 286 | 33142.8 | 2 | UniProt (P00519) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1, P150, C-ABL |
| 2 | C, E (A, B) | N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE | non-polymer | 474.6 | 2 | Chemie (627) | |||
| 3 | D, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 166 | Chemie (HOH) |
Sequence modifications
A, B: 227 - 228 (PDB: 2V7A)
A, B: 229 - 512 (UniProt: P00519)
A, B: 229 - 512 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Ile 315 | Thr 315 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66285.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 997.7 | |
| All* | Total formula weight | 67283.3 |
