2V7A

Crystal structure of the T315I Abl mutant in complex with the inhibitor PHA-739358

2V7A の概要

関連するPDBエントリー1AB2 1JU5 2F4J 2G2F 2GQG 1ABL 1AWO 1BBZ 1OPL 1ZZP 2ABL 2FO0 2G2H
分子名称PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1, N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, MAGNESIUM ION, ... (4 entities in total)
機能のキーワードkinase, nucleus, myristate, cytoplasm, manganese, cell adhesion, metal-binding, proto-oncogene, tyrosine-protein kinase, chromosomal rearrangement, transferase, lipoprotein, polymorphism, cytoskeleton, magnesium, sh2 domain, sh3 domain, atp-binding, nucleotide-binding, alternative splicing, phosphorylation, kinase inhibitor, t315i abl mutant
由来する生物種HOMO SAPIENS (HUMAN)
ポリマー鎖数2
分子量合計67283.31
構造登録者
主引用文献
Modugno, M.,Casale, E.,Soncini, C.,Rosettani, P.,Colombo, R.,Lupi, R.,Rusconi, L.,Fancelli, D.,Carpinelli, P.,Cameron, A.D.,Isacchi, A.,Moll, J.
Crystal Structure of the T315I Abl Mutant in Complex with the Aurora Kinases Inhibitor Pha-739358.
Cancer Res., 67:7987-, 2007
PubMed: 17804707 (主引用文献が同じPDBエントリー)
DOI: 10.1158/0008-5472.CAN-07-1825
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.5 Å)
NMR情報
?

構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23950 4.9% 4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)ダウンロードをダウンロード