2V7A

Crystal structure of the T315I Abl mutant in complex with the inhibitor PHA-739358

2V7A の概要

• エントリーDOI: 10.2210/pdb2v7a/pdb
• 関連するPDBエントリー: 1AB2 1ABL 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2F4J 2FO0 2G2F 2G2H 2GQG
• 分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1, N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: kinase, nucleus, myristate, cytoplasm, manganese, cell adhesion, metal-binding, proto-oncogene, tyrosine-protein kinase, chromosomal rearrangement, transferase, lipoprotein, polymorphism, cytoskeleton, magnesium, sh2 domain, sh3 domain, atp-binding, nucleotide-binding, alternative splicing, phosphorylation, kinase inhibitor, t315i abl mutant
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67283.31

構造登録者

Modugno, M.,Casale, E.,Soncini, C.,Rosettani, P.,Colombo, R.,Lupi, R.,Rusconi, L.,Fancelli, D.,Carpinelli, P.,Cameron, A.D.,Isacchi, A.,Moll, J. (登録日: 2007-07-27, 公開日: 2007-09-18, 最終更新日: 2023-12-13)

• 主引用文献: Modugno, M.,Casale, E.,Soncini, C.,Rosettani, P.,Colombo, R.,Lupi, R.,Rusconi, L.,Fancelli, D.,Carpinelli, P.,Cameron, A.D.,Isacchi, A.,Moll, J.; Crystal Structure of the T315I Abl Mutant in Complex with the Aurora Kinases Inhibitor Pha-739358.; Cancer Res., 67:7987-, 2007; PubMed: 17804707; DOI: 10.1158/0008-5472.CAN-07-1825

実験手法

X-RAY DIFFRACTION (2.5 Å)