2QCN

Covalent complex of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase with 6-iodo-UMP

2QCN の概要

• エントリーDOI: 10.2210/pdb2qcn/pdb
• 関連するPDBエントリー: 2JGY 2QCC 2QCD 2QCE 2QCF 2QCG 2QCH 2QCL 2QCM 2V30
• 分子名称: Uridine 5'-monophosphate synthase, SULFATE ION, URIDINE-5'-MONOPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: ump synthase, decarboxylase, catalytic proficiency, disease mutation, glycosyltransferase, lyase, multifunctional enzyme, pyrimidine biosynthesis, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57528.10

構造登録者

Wittmann, J.,Rudolph, M. (登録日: 2007-06-19, 公開日: 2007-11-13, 最終更新日: 2011-07-13)

• 主引用文献: Wittmann, J.G.,Heinrich, D.,Gasow, K.,Frey, A.,Diederichsen, U.,Rudolph, M.G.; Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design.; Structure, 16:82-92, 2008; PubMed: 18184586; DOI: 10.1016/j.str.2007.10.020

実験手法

X-RAY DIFFRACTION (1.85 Å)