2QCN
Covalent complex of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase with 6-iodo-UMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Uridine 5'-monophosphate synthase | polymer | 260 | 28299.7 | 2 | UniProt (P11172) Pfam (PF00215) In PDB | Homo sapiens (human) | UMP synthase [Includes: Orotate phosphoribosyltransferase (E.C. 2.4.2.10) (OPRTase), and Orotidine 5'-phosphate decarboxylase (E.C. 4.1.1.23) (OMPdecase)] |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | A, B | URIDINE-5'-MONOPHOSPHATE | non-polymer | 324.2 | 2 | Chemie (U5P) | |||
| 4 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 410 | Chemie (HOH) |
Sequence modifications
A, B: 224 - 480 (UniProt: P11172)
| PDB | External Database | Details |
|---|---|---|
| Gly 221 | - | EXPRESSION TAG |
| Ala 222 | - | EXPRESSION TAG |
| Met 223 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 56599.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 928.6 | |
| All* | Total formula weight | 57528.1 |
