2QCN
Covalent complex of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase with 6-iodo-UMP
Summary for 2QCN
Entry DOI | 10.2210/pdb2qcn/pdb |
Related | 2JGY 2QCC 2QCD 2QCE 2QCF 2QCG 2QCH 2QCL 2QCM 2V30 |
Descriptor | Uridine 5'-monophosphate synthase, SULFATE ION, URIDINE-5'-MONOPHOSPHATE, ... (5 entities in total) |
Functional Keywords | ump synthase, decarboxylase, catalytic proficiency, disease mutation, glycosyltransferase, lyase, multifunctional enzyme, pyrimidine biosynthesis, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 57528.10 |
Authors | Wittmann, J.,Rudolph, M. (deposition date: 2007-06-19, release date: 2007-11-13, Last modification date: 2011-07-13) |
Primary citation | Wittmann, J.G.,Heinrich, D.,Gasow, K.,Frey, A.,Diederichsen, U.,Rudolph, M.G. Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design. Structure, 16:82-92, 2008 Cited by PubMed: 18184586DOI: 10.1016/j.str.2007.10.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report