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2QCF

Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to 5-fluoro-UMP

Summary for 2QCF
Entry DOI10.2210/pdb2qcf/pdb
Related2jgy 2qcc 2qcd 2qce 2v30
DescriptorUridine 5'-monophosphate synthase (UMP synthase), 5-FLUORO-URIDINE-5'-MONOPHOSPHATE, GLYCEROL, ... (4 entities in total)
Functional Keywordsump synthase, decarboxylase, catalytic proficiency, lyase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight28765.09
Authors
Wittmann, J.,Rudolph, M. (deposition date: 2007-06-19, release date: 2007-11-06, Last modification date: 2021-10-20)
Primary citationWittmann, J.G.,Heinrich, D.,Gasow, K.,Frey, A.,Diederichsen, U.,Rudolph, M.G.
Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design.
Structure, 16:82-92, 2008
Cited by
PubMed: 18184586
DOI: 10.1016/j.str.2007.10.020
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.22 Å)
Structure validation

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