2PWC
HIV-1 protease in complex with a amino decorated pyrrolidine-based inhibitor
Summary for 2PWC
| Entry DOI | 10.2210/pdb2pwc/pdb |
| Related | 1XL2 2PQZ 2PWR |
| Descriptor | Gag-Pol polyprotein (Pr160Gag-Pol), CHLORIDE ION, N,N'-(3S,4S)-PYRROLIDINE-3,4-DIYLBIS(4-AMINO-N-BENZYLBENZENESULFONAMIDE), ... (5 entities in total) |
| Functional Keywords | protein-ligand complex, hydrolase |
| Biological source | Human immunodeficiency virus 1 |
| Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
| Total number of polymer chains | 2 |
| Total formula weight | 22397.71 |
| Authors | Boettcher, J.,Blum, A.,Heine, A.,Diederich, W.E.,Klebe, G. (deposition date: 2007-05-11, release date: 2008-04-15, Last modification date: 2024-03-13) |
| Primary citation | Blum, A.,Bottcher, J.,Heine, A.,Klebe, G.,Diederich, W.E. Structure-Guided Design of C2-Symmetric HIV-1 Protease Inhibitors Based on a Pyrrolidine Scaffold. J.Med.Chem., 51:2078-2087, 2008 Cited by PubMed: 18348517DOI: 10.1021/jm701142s PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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