1XL2

HIV-1 Protease in complex with pyrrolidinmethanamine

Summary for 1XL2

• Entry DOI: 10.2210/pdb1xl2/pdb
• Related: 1AJX 1HVI 1XL5
• Descriptor: PROTEASE RETROPEPSIN, CHLORIDE ION, N-BENZYL-2-(2,6-DIMETHYLPHENOXY)-N-[((3R,4S)-4-{[ISOBUTYL(PHENYLSULFONYL)AMINO]METHYL}PYRROLIDIN-3-YL)METHYL]ACETAMIDE, ... (5 entities in total)
• Functional Keywords: aspartyl protease; hiv protease; pyrrolidine inhibitor, hydrolase
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• Total number of polymer chains: 2
• Total formula weight: 22348.29

Authors

Boettcher, J.,Specker, E.,Heine, A.,Klebe, G. (deposition date: 2004-09-30, release date: 2005-06-07, Last modification date: 2023-08-23)

• Primary citation: Specker, E.,Boettcher, J.,Lilie, H.,Heine, A.,Schoop, A.,Muller, G.,Griebenow, N.,Klebe, G.; An Old Target Revisited: Two New Privileged Skeletons and an Unexpected Binding Mode For HIV-Protease Inhibitors; Angew.Chem.Int.Ed.Engl., 44:3140-3144, 2005; PubMed: 15822136; DOI: 10.1002/anie.200462643

Experimental method

X-RAY DIFFRACTION (1.5 Å)