Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2PWC

HIV-1 protease in complex with a amino decorated pyrrolidine-based inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004190molecular_functionaspartic-type endopeptidase activity
A0006508biological_processproteolysis
B0004190molecular_functionaspartic-type endopeptidase activity
B0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL B 701
ChainResidue
BTRP6
BLYS55

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 702
ChainResidue
ATHR74
AASN88
BARG41

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL B 703
ChainResidue
BTHR74
BASN88
BHOH732
BHOH770

site_idAC4
Number of Residues17
DetailsBINDING SITE FOR RESIDUE G3G A 501
ChainResidue
AASP25
AGLY27
AALA28
AASP30
AGLY48
AILE50
AILE84
BASP25
BGLY27
BALA28
BASP30
BGLY48
BGLY49
BILE50
BPRO81
BILE84
BHOH736

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 601
ChainResidue
AARG8
APRO81
AHOH744
AHOH757
BGLY48
BHOH718

Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL
ChainResidueDetails
AALA22-LEU33

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094
ChainResidueDetails
AASP25
BASP25

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage; by viral protease => ECO:0000250
ChainResidueDetails
APHE99
BPHE99

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a30
ChainResidueDetails
AASP25
ATHR26

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a30
ChainResidueDetails
BASP25
BTHR26

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1a30
ChainResidueDetails
AASP25

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1a30
ChainResidueDetails
BASP25

227344

PDB entries from 2024-11-13

PDB statisticsPDBj update infoContact PDBjnumon