2PT9
The structure of Plasmodium falciparum spermidine synthase in complex with decarboxylated S-adenosylmethionine and the inhibitor cis-4-methylcyclohexylamine (4MCHA)
Summary for 2PT9
Entry DOI | 10.2210/pdb2pt9/pdb |
Related | 2HTE 2I7C 2PSS 2PT6 |
Descriptor | Spermidine synthase, 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, cis-4-methylcyclohexanamine, ... (7 entities in total) |
Functional Keywords | transferase, spermidine synthase, structural genomics consortium, sgc, inhibitor complex, structural biology of malarial parasites and other apicomplexans |
Biological source | Plasmodium falciparum |
Total number of polymer chains | 3 |
Total formula weight | 112207.28 |
Authors | Dufe, V.T.,Qiu, W.,Muller, I.B.,Hui, R.,Walter, R.D.,Al-Karadaghi, S.,Structural Genomics Consortium (SGC) (deposition date: 2007-05-08, release date: 2008-04-01, Last modification date: 2023-08-30) |
Primary citation | Dufe, V.T.,Qiu, W.,Muller, I.B.,Hui, R.,Walter, R.D.,Al-Karadaghi, S. Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO. J.Mol.Biol., 373:167-177, 2007 Cited by PubMed: 17822713DOI: 10.1016/j.jmb.2007.07.053 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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