2I7C
The crystal structure of spermidine synthase from p. falciparum in complex with AdoDATO
Summary for 2I7C
Entry DOI | 10.2210/pdb2i7c/pdb |
Related | 1JQ3 1ZDZ 2HTE |
Descriptor | Spermidine synthase, S-ADENOSYL-1,8-DIAMINO-3-THIOOCTANE, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, ... (5 entities in total) |
Functional Keywords | transferase, spermidine synthase, structural genomics consortium, sgc |
Biological source | Plasmodium falciparum |
Total number of polymer chains | 3 |
Total formula weight | 98714.94 |
Authors | Qiu, W.,Dong, A.,Ren, H.,Wu, H.,Wasney, G.,Vedadi, M.,Lew, J.,Kozieradski, I.,Edwards, A.M.,Arrowsmith, C.H.,Weigelt, J.,Sundstrom, M.,Plotnikov, A.N.,Bochkarev, A.,Hui, R.,Structural Genomics Consortium (SGC) (deposition date: 2006-08-30, release date: 2006-09-12, Last modification date: 2023-08-30) |
Primary citation | Dufe, V.T.,Qiu, W.,Muller, I.B.,Hui, R.,Walter, R.D.,Al-Karadaghi, S. Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO. J.Mol.Biol., 373:167-177, 2007 Cited by PubMed: 17822713DOI: 10.1016/j.jmb.2007.07.053 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.71 Å) |
Structure validation
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