2I7C

The crystal structure of spermidine synthase from p. falciparum in complex with AdoDATO

Summary for 2I7C

Entry DOI	10.2210/pdb2i7c/pdb
Related	1JQ3 1ZDZ 2HTE
Descriptor	Spermidine synthase, S-ADENOSYL-1,8-DIAMINO-3-THIOOCTANE, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, ... (5 entities in total)
Functional Keywords	transferase, spermidine synthase, structural genomics consortium, sgc
Biological source	Plasmodium falciparum
Total number of polymer chains	3
Total formula weight	98714.94
Authors	Qiu, W.,Dong, A.,Ren, H.,Wu, H.,Wasney, G.,Vedadi, M.,Lew, J.,Kozieradski, I.,Edwards, A.M.,Arrowsmith, C.H.,Weigelt, J.,Sundstrom, M.,Plotnikov, A.N.,Bochkarev, A.,Hui, R.,Structural Genomics Consortium (SGC) (deposition date: 2006-08-30, release date: 2006-09-12, Last modification date: 2023-08-30)
Primary citation	Dufe, V.T.,Qiu, W.,Muller, I.B.,Hui, R.,Walter, R.D.,Al-Karadaghi, S. Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO. J.Mol.Biol., 373:167-177, 2007 Cited by PubMed: 17822713 DOI: 10.1016/j.jmb.2007.07.053 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation