2PT6

The structure of Plasmodium falciparum spermidine synthase in complex with decarboxylated S-adenosylmethionine

Summary for 2PT6

• Entry DOI: 10.2210/pdb2pt6/pdb
• Related: 2HTE 2I7C 2PSS 2PT9
• Descriptor: Spermidine synthase, 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, ... (5 entities in total)
• Functional Keywords: transferase, spermidine synthase, structural genomics consortium, sgc, dcadomet complex
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 3
• Total formula weight: 111771.62

Authors

Dufe, V.T.,Qiu, W.,Muller, I.B.,Hui, R.,Walter, R.D.,Al-Karadaghi, S.,Structural Genomics Consortium (SGC) (deposition date: 2007-05-08, release date: 2008-04-01, Last modification date: 2023-08-30)

• Primary citation: Dufe, V.T.,Qiu, W.,Muller, I.B.,Hui, R.,Walter, R.D.,Al-Karadaghi, S.; Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO.; J.Mol.Biol., 373:167-177, 2007; PubMed: 17822713; DOI: 10.1016/j.jmb.2007.07.053

Experimental method

X-RAY DIFFRACTION (2 Å)