2PT9
The structure of Plasmodium falciparum spermidine synthase in complex with decarboxylated S-adenosylmethionine and the inhibitor cis-4-methylcyclohexylamine (4MCHA)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004766 | molecular_function | spermidine synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006596 | biological_process | polyamine biosynthetic process |
| A | 0008295 | biological_process | spermidine biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004766 | molecular_function | spermidine synthase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006596 | biological_process | polyamine biosynthetic process |
| B | 0008295 | biological_process | spermidine biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004766 | molecular_function | spermidine synthase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006596 | biological_process | polyamine biosynthetic process |
| C | 0008295 | biological_process | spermidine biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 604 |
| Chain | Residue |
| B | HIS236 |
| B | GLY238 |
| B | THR239 |
| B | LYS291 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE S4M A 501 |
| Chain | Residue |
| A | ASP127 |
| A | CYS146 |
| A | GLU147 |
| A | ILE148 |
| A | ASP178 |
| A | ALA179 |
| A | ASP196 |
| A | SER198 |
| A | PRO203 |
| A | ALA204 |
| A | THR206 |
| A | LEU207 |
| A | GLN72 |
| A | GLN93 |
| A | HIS103 |
| A | GLY124 |
| A | GLY125 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE S4M B 502 |
| Chain | Residue |
| B | GLN72 |
| B | LEU88 |
| B | GLN93 |
| B | TYR102 |
| B | HIS103 |
| B | GLY124 |
| B | GLY125 |
| B | ASP127 |
| B | CYS146 |
| B | GLU147 |
| B | ILE148 |
| B | ASP178 |
| B | ALA179 |
| B | ASP196 |
| B | SER198 |
| B | PRO203 |
| B | ALA204 |
| B | THR206 |
| B | LEU207 |
| B | HOH614 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE S4M C 503 |
| Chain | Residue |
| C | GLN71 |
| C | GLN92 |
| C | TYR101 |
| C | HIS102 |
| C | GLY123 |
| C | ASP126 |
| C | CYS145 |
| C | GLU146 |
| C | ILE147 |
| C | GLU176 |
| C | ASP177 |
| C | ALA178 |
| C | ASP195 |
| C | SER197 |
| C | PRO202 |
| C | ALA203 |
| C | LEU206 |
| C | TYR263 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE 2MH A 401 |
| Chain | Residue |
| A | GLN93 |
| A | ASP199 |
| A | TYR264 |
| A | HOH724 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 2MH B 402 |
| Chain | Residue |
| B | ILE92 |
| B | GLN93 |
| B | TYR102 |
| B | SER197 |
| B | ASP199 |
| B | TYR264 |
| B | ILE269 |
| B | HOH606 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 2MH C 403 |
| Chain | Residue |
| C | TRP50 |
| C | ILE91 |
| C | GLN92 |
| C | SER196 |
| C | ASP198 |
| C | TYR263 |
| C | PRO264 |
| C | ILE268 |
| C | HOH755 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE 1PG A 701 |
| Chain | Residue |
| A | TRP43 |
| A | SER45 |
| A | PHE47 |
| A | SER57 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 1PG C 702 |
| Chain | Residue |
| B | LYS42 |
| B | PHE47 |
| B | SER57 |
| C | SER44 |
| C | PHE46 |
| C | SER56 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 601 |
| Chain | Residue |
| B | LYS97 |
| B | HOH651 |
| C | TRP233 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 602 |
| Chain | Residue |
| B | TRP234 |
| C | LYS96 |
| C | PHE99 |
| C | HOH772 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 603 |
| Chain | Residue |
| A | TRP234 |
| A | LYS97 |
| A | PHE100 |
Functional Information from PROSITE/UniProt
| site_id | PS01330 |
| Number of Residues | 14 |
| Details | PABS_1 Polyamine biosynthesis (PABS) domain signature. VLVVGGGdGgiIrE |
| Chain | Residue | Details |
| A | VAL120-GLU133 |
