2PDF

Human aldose reductase mutant L300P complexed with zopolrestat.

Summary for 2PDF

Related2AGT 2HVN 2PD5 2PD9 2PDB 2PDC 2PDG 2PDH 2PDI 2PDJ 2PDK 2PDL 2PDM 2PDN 2PDP 2PDQ 2PDU 2PDW 2PDX 2PDY
DescriptorAldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ... (4 entities in total)
Functional Keywordstim barrel, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P15121
Total number of polymer chains1
Total molecular weight37045.08
Authors
Steuber, H.,Heine, A.,Klebe, G. (deposition date: 2007-03-31, release date: 2008-04-01, Last modification date: 2011-07-13)
Primary citation
Steuber, H.,Heine, A.,Podjarny, A.,Klebe, G.
Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features.
J.Mol.Biol., 379:991-1016, 2008
PubMed: 18495158 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2008.03.063
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.56 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.225504.6%5.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

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