2PD9

Human aldose reductase mutant V47I complexed with fidarestat.

Summary for 2PD9

Entry DOI	10.2210/pdb2pd9/pdb
Related	1PWM 2PD5 2PDB 2PDC 2PDF 2PDG 2PDH 2PDI 2PDJ 2PDK 2PDL 2PDM 2PDN 2PDP 2PDQ 2PDU 2PDW 2PDX 2PDY
Descriptor	Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, ... (4 entities in total)
Functional Keywords	protein-ligand complex, tim-barrel, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	36935.00
Authors	Steuber, H.,Heine, A.,Klebe, G. (deposition date: 2007-03-31, release date: 2008-04-01, Last modification date: 2023-08-30)
Primary citation	Steuber, H.,Heine, A.,Podjarny, A.,Klebe, G. Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features. J.Mol.Biol., 379:991-1016, 2008 Cited by PubMed: 18495158 DOI: 10.1016/j.jmb.2008.03.063 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation