Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2PDF

Human aldose reductase mutant L300P complexed with zopolrestat.

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AAldose reductasepolymer31635882.31UniProt (P15121)
Pfam (PF00248)
In PDB
Homo sapiens (human)AR, Aldehyde reductase
2ANADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer743.41Chemie (NAP)
3A3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACIDnon-polymer419.41Chemie (ZST)
4waterwater18.0254Chemie (HOH)
Sequence modifications
A: 0 - 315 (UniProt: P15121)
PDBExternal DatabaseDetails
Ile 4Leu 5conflict
Pro 300Leu 301engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight35882.3
Non-Polymers*Number of molecules2
Total formula weight1162.8
All*Total formula weight37045.1
*Water molecules are not included.

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon