Solution Structure of the Complex Between BCL-xL and the p53 Core Domain determined with PRE restraints

Summary for 2MEJ

Related2ME8 2ME9 2AC0
DescriptorBcl-2-like protein 1, Cellular tumor antigen p53, ZINC ION (3 entities in total)
Functional Keywordsbcl-xl, p53, apoptosis, bcl-2 family, cytoplasmic p53, selective labeling
Biological sourceHomo sapiens (human)
Cellular locationIsoform Bcl-X(L): Mitochondrion inner membrane  Q07817
Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm P04637
Total number of polymer chains2
Total molecular weight48148.08
Viacava Follis, A.,Grace, C.R.,Kriwacki, R.W. (deposition date: 2013-09-25, release date: 2014-04-30, Last modification date: 2016-04-27)
Primary citation
Follis, A.V.,Llambi, F.,Ou, L.,Baran, K.,Green, D.R.,Kriwacki, R.W.
The DNA-binding domain mediates both nuclear and cytosolic functions of p53.
Nat.Struct.Mol.Biol., 21:535-543, 2014
PubMed: 24814347 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb.2829
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers41.1%14.4%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation report