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2MEJ

Solution Structure of the Complex Between BCL-xL and the p53 Core Domain determined with PRE restraints

Functional Information from GO Data
ChainGOidnamespacecontents
A0001541biological_processovarian follicle development
A0001701biological_processin utero embryonic development
A0001836biological_processrelease of cytochrome c from mitochondria
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005743cellular_componentmitochondrial inner membrane
A0005759cellular_componentmitochondrial matrix
A0005783cellular_componentendoplasmic reticulum
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006897biological_processendocytosis
A0006915biological_processapoptotic process
A0006950biological_processresponse to stress
A0007005biological_processmitochondrion organization
A0007281biological_processgerm cell development
A0007283biological_processspermatogenesis
A0008584biological_processmale gonad development
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0008637biological_processapoptotic mitochondrial changes
A0009314biological_processresponse to radiation
A0009566biological_processfertilization
A0009615biological_processresponse to virus
A0015267molecular_functionchannel activity
A0016020cellular_componentmembrane
A0019901molecular_functionprotein kinase binding
A0030672cellular_componentsynaptic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0031965cellular_componentnuclear membrane
A0031966cellular_componentmitochondrial membrane
A0032465biological_processregulation of cytokinesis
A0032946biological_processpositive regulation of mononuclear cell proliferation
A0034097biological_processresponse to cytokine
A0035234biological_processectopic germ cell programmed cell death
A0040008biological_processregulation of growth
A0042802molecular_functionidentical protein binding
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0044565biological_processdendritic cell proliferation
A0045202cellular_componentsynapse
A0046898biological_processresponse to cycloheximide
A0046902biological_processregulation of mitochondrial membrane permeability
A0050673biological_processepithelial cell proliferation
A0051093biological_processnegative regulation of developmental process
A0051402biological_processneuron apoptotic process
A0051434molecular_functionBH3 domain binding
A0051607biological_processdefense response to virus
A0051707biological_processresponse to other organism
A0051881biological_processregulation of mitochondrial membrane potential
A0055085biological_processtransmembrane transport
A0071230biological_processcellular response to amino acid stimulus
A0071312biological_processcellular response to alkaloid
A0071480biological_processcellular response to gamma radiation
A0071839biological_processapoptotic process in bone marrow cell
A0090201biological_processnegative regulation of release of cytochrome c from mitochondria
A0097048biological_processdendritic cell apoptotic process
A0097136cellular_componentBcl-2 family protein complex
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0097284biological_processhepatocyte apoptotic process
A1900118biological_processnegative regulation of execution phase of apoptosis
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
A1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
A1902531biological_processregulation of intracellular signal transduction
A1903077biological_processnegative regulation of protein localization to plasma membrane
A2000242biological_processnegative regulation of reproductive process
A2000669biological_processnegative regulation of dendritic cell apoptotic process
A2001233biological_processregulation of apoptotic signaling pathway
A2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
A2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
B0000976molecular_functiontranscription cis-regulatory region binding
B0003677molecular_functionDNA binding
B0003700molecular_functionDNA-binding transcription factor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
B0006915biological_processapoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 401
ChainResidue
BCYS176
BHIS179
BCYS238
BCYS242

Functional Information from PROSITE/UniProt
site_idPS00348
Number of Residues13
DetailsP53 p53 family signature. MCNSSCMGGMNRR
ChainResidueDetails
BMET237-ARG249

site_idPS01080
Number of Residues19
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFsFGG
ChainResidueDetails
ALEU133-GLY151

site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV
ChainResidueDetails
ATRP184-VAL195

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR
ChainResidueDetails
AVAL89-ARG103

site_idPS01260
Number of Residues21
DetailsBH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW
ChainResidueDetails
ASER7-TRP27

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsMotif: {"description":"BH4"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues14
DetailsMotif: {"description":"BH3"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues19
DetailsMotif: {"description":"BH1"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues15
DetailsMotif: {"description":"BH2"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues123
DetailsRegion: {"description":"Required for interaction with FBXO42","evidences":[{"source":"PubMed","id":"19509332","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues7
DetailsRegion: {"description":"Interaction with the 53BP2 SH3 domain"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues7
DetailsRegion: {"description":"Interaction with DNA"}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"14534297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16793544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17015838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18650397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19515728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20142040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20364130","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues1
DetailsSite: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"16793544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18996393","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20364130","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues2
DetailsModified residue: {"description":"N6-lactoyllysine","evidences":[{"source":"PubMed","id":"38653238","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by AURKB","evidences":[{"source":"PubMed","id":"20959462","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by AURKB","evidences":[{"source":"PubMed","id":"20959462","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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