2ME8

Solution Structure of BCL-xL in its p53-bound conformation determined with selective isotope labelling of I,L,V sidechains

Summary for 2ME8

• Entry DOI: 10.2210/pdb2me8/pdb
• Related: 2ME9 2MEJ
• NMR Information: BMRB: 19520
• Descriptor: Bcl-2-like protein 1 (1 entity in total)
• Functional Keywords: bcl-xl, p53, apoptosis, bcl-2 family, cytoplasmic p53, selective labeling
• Biological source: Homo sapiens (human)
• Cellular location: Isoform Bcl-X(L): Mitochondrion inner membrane (By similarity): Q07817
• Total number of polymer chains: 1
• Total formula weight: 23669.94

Authors

Viacava Follis, A.,Grace, C.R.,Kriwacki, R.W. (deposition date: 2013-09-25, release date: 2014-04-30, Last modification date: 2023-06-14)

• Primary citation: Follis, A.V.,Llambi, F.,Ou, L.,Baran, K.,Green, D.R.,Kriwacki, R.W.; The DNA-binding domain mediates both nuclear and cytosolic functions of p53.; Nat.Struct.Mol.Biol., 21:535-543, 2014; PubMed: 24814347; DOI: 10.1038/nsmb.2829

Experimental method

SOLUTION NMR