2MEJ
Solution Structure of the Complex Between BCL-xL and the p53 Core Domain determined with PRE restraints
Summary for 2MEJ
Entry DOI | 10.2210/pdb2mej/pdb |
Related | 2AC0 2ME8 2ME9 |
NMR Information | BMRB: 19522 |
Descriptor | Bcl-2-like protein 1, Cellular tumor antigen p53, ZINC ION (3 entities in total) |
Functional Keywords | bcl-xl, p53, apoptosis, bcl-2 family, cytoplasmic p53, selective labeling |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817 Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 2 |
Total formula weight | 48148.07 |
Authors | Viacava Follis, A.,Grace, C.R.,Kriwacki, R.W. (deposition date: 2013-09-25, release date: 2014-04-30, Last modification date: 2024-05-15) |
Primary citation | Follis, A.V.,Llambi, F.,Ou, L.,Baran, K.,Green, D.R.,Kriwacki, R.W. The DNA-binding domain mediates both nuclear and cytosolic functions of p53. Nat.Struct.Mol.Biol., 21:535-543, 2014 Cited by PubMed: 24814347DOI: 10.1038/nsmb.2829 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report