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2ME8

Solution Structure of BCL-xL in its p53-bound conformation determined with selective isotope labelling of I,L,V sidechains

Functional Information from GO Data
ChainGOidnamespacecontents
A0001541biological_processovarian follicle development
A0001701biological_processin utero embryonic development
A0001836biological_processrelease of cytochrome c from mitochondria
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005743cellular_componentmitochondrial inner membrane
A0005759cellular_componentmitochondrial matrix
A0005783cellular_componentendoplasmic reticulum
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006897biological_processendocytosis
A0006915biological_processapoptotic process
A0007005biological_processmitochondrion organization
A0007281biological_processgerm cell development
A0007283biological_processspermatogenesis
A0008584biological_processmale gonad development
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0008637biological_processapoptotic mitochondrial changes
A0009314biological_processresponse to radiation
A0009566biological_processfertilization
A0009615biological_processresponse to virus
A0015267molecular_functionchannel activity
A0016020cellular_componentmembrane
A0019901molecular_functionprotein kinase binding
A0030672cellular_componentsynaptic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0031965cellular_componentnuclear membrane
A0031966cellular_componentmitochondrial membrane
A0032465biological_processregulation of cytokinesis
A0032946biological_processpositive regulation of mononuclear cell proliferation
A0034097biological_processresponse to cytokine
A0035234biological_processectopic germ cell programmed cell death
A0040008biological_processregulation of growth
A0042802molecular_functionidentical protein binding
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0044565biological_processdendritic cell proliferation
A0045202cellular_componentsynapse
A0046898biological_processresponse to cycloheximide
A0046902biological_processregulation of mitochondrial membrane permeability
A0050673biological_processepithelial cell proliferation
A0051093biological_processnegative regulation of developmental process
A0051402biological_processneuron apoptotic process
A0051434molecular_functionBH3 domain binding
A0051607biological_processdefense response to virus
A0051881biological_processregulation of mitochondrial membrane potential
A0055085biological_processtransmembrane transport
A0071230biological_processcellular response to amino acid stimulus
A0071312biological_processcellular response to alkaloid
A0071480biological_processcellular response to gamma radiation
A0071839biological_processapoptotic process in bone marrow cell
A0090201biological_processnegative regulation of release of cytochrome c from mitochondria
A0097048biological_processdendritic cell apoptotic process
A0097136cellular_componentBcl-2 family protein complex
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0097284biological_processhepatocyte apoptotic process
A1900118biological_processnegative regulation of execution phase of apoptosis
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
A1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
A1902531biological_processregulation of intracellular signal transduction
A1903077biological_processnegative regulation of protein localization to plasma membrane
A2000242biological_processnegative regulation of reproductive process
A2000669biological_processnegative regulation of dendritic cell apoptotic process
A2001233biological_processregulation of apoptotic signaling pathway
A2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
A2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS01080
Number of Residues19
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFsFGG
ChainResidueDetails
ALEU133-GLY151

site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV
ChainResidueDetails
ATRP184-VAL195

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR
ChainResidueDetails
AVAL89-ARG103

site_idPS01260
Number of Residues21
DetailsBH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW
ChainResidueDetails
ASER7-TRP27

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by caspase-1
ChainResidueDetails
AASP64

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PLK3 => ECO:0000269|PubMed:21840391
ChainResidueDetails
ASER52

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:19917720
ChainResidueDetails
ASER65

227561

PDB entries from 2024-11-20

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