2J9Y

Tryptophan Synthase Q114N mutant in complex with Compound II

2J9Y の概要

• エントリーDOI: 10.2210/pdb2j9y/pdb
• 関連するPDBエントリー: 1A50 1A5A 1A5B 1A5S 1BEU 1BKS 1C29 1C8V 1C9D 1CW2 1CX9 1FUY 1K3U 1K7E 1K7F 1K7X 1K8X 1K8Y 1K8Z 1KFB 1KFC 1KFE 1KFJ 1KFK 1QOP 1QOQ 1TJP 1TTP 1UBS 1WBJ 2CLE 2CLF 2CLI 2CLK 2CLL 2CLM 2CLO 2J9X 2J9Z 2TRS 2TSY 2TYS 2WSY
• 分子名称: TRYPTOPHAN SYNTHASE ALPHA CHAIN, TRYPTOPHAN SYNTHASE BETA CHAIN, (3E)-4-{3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}-2-IMINOBUT-3-ENOIC ACID, ... (5 entities in total)
• 機能のキーワード: aromatic amino acid biosynthesis, tryptophan biosynthesis, lyase carbon- oxygen lyase, amino-acid biosynthesis, lyase, allosteric enzyme, pyridoxal phosphate
• 由来する生物種: SALMONELLA TYPHIMURIUM; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71942.85

構造登録者

Blumenstein, L.,Domratcheva, T.,Niks, D.,Ngo, H.,Seidel, R.,Dunn, M.F.,Schlichting, I. (登録日: 2006-11-16, 公開日: 2007-12-04, 最終更新日: 2011-07-13)

• 主引用文献: Blumenstein, L.,Domratcheva, T.,Niks, D.,Ngo, H.,Seidel, R.,Dunn, M.F.,Schlichting, I.; Betaq114N and Betat110V Mutations Reveal a Critically Important Role of the Substrate Alpha-Carboxylate Site in the Reaction Specificity of Tryptophan Synthase.; Biochemistry, 46:14100-, 2007; PubMed: 18004874; DOI: 10.1021/BI7008568

実験手法

X-RAY DIFFRACTION (1.8 Å)