1A5B
CRYO-CRYSTALLOGRAPHY OF A TRUE SUBSTRATE, INDOLE-3-GLYCEROL PHOSPHATE, BOUND TO A MUTANT (ALPHA D60N) TRYPTOPHAN SYNTHASE ALPHA2BETA2 COMPLEX REVEALS THE CORRECT ORIENTATION OF ACTIVE SITE ALPHA GLU 49
Summary for 1A5B
Entry DOI | 10.2210/pdb1a5b/pdb |
Descriptor | TRYPTOPHAN SYNTHASE (ALPHA CHAIN), TRYPTOPHAN SYNTHASE (BETA CHAIN), INDOLE-3-GLYCEROL PHOSPHATE, ... (6 entities in total) |
Functional Keywords | carbon-oxygen lyase, mutation at position 60 (asp --> asn) in the a-subunit, true substrate indole-3-glycerol phosphate in the a-subunit, lyase |
Biological source | Salmonella typhimurium More |
Total number of polymer chains | 2 |
Total formula weight | 72244.30 |
Authors | Rhee, S.,Miles, E.W.,Davies, D.R. (deposition date: 1998-02-12, release date: 1998-05-27, Last modification date: 2021-11-03) |
Primary citation | Rhee, S.,Miles, E.W.,Davies, D.R. Cryo-crystallography of a true substrate, indole-3-glycerol phosphate, bound to a mutant (alphaD60N) tryptophan synthase alpha2beta2 complex reveals the correct orientation of active site alphaGlu49. J.Biol.Chem., 273:8553-8555, 1998 Cited by PubMed: 9535826DOI: 10.1074/jbc.273.15.8553 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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